We love ribosomes and everything about how they are made in the nucleolus. Critical for growth in all eukaryotic cells, since the 19th century the nucleolus has been implicated in the pathogenesis of cancer. More recently, there are a growing number of human genetic diseases linked to mutations in nucleolar factors, causing a wide variety of perplexing symptomatology.
CREDIT: C. BICKEL/SCIENCE
KL McCann and SJ Baserga. 2013. Mysterious Ribosomopathies. Science 341 (6148): 849-850.
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