Select Publications

2023

  • McCool M.A., Bryant C.J., Huang H., Ogawa L.M., Farley-Barnes K.I., Sondalle S.B., Abriola L., Surovtseva Y.V., Baserga S.J. Human nucleolar protein 7 (NOL7) is required for early pre-rRNA accumulation and pre-18S processing. RNA Biology 2023, doi:10.1080/15476286.2023.2217392

  • Bryant C.J., McCool M.A., Rasado-González G.T., Abriola L., Surovtseva Y.V., Baserga S.J. Discovery of novel microRNA regulators of ribosome biogenesis. bioRxiv (preprint) 2023, doi:10.1101/2023.02.17.526327

2022

  • *McCool M.A., *Buhagiar A.F., Bryant C.J., Ogawa L.M., Abriola L., Surovtseva Y.V., Baserga S.J. Human pre-60S assembly factors link rRNA transcription to pre-rRNA processing. RNA 2022, doi:10.1261/rna.079149.122 *Equal contributions
  • McFadden E.J., Baserga S.J. U8 variants on the brain: a small nucleolar RNA and human disease. RNA Biology 2022, doi:10.1080/15476286.2022.2048563
  • *Bryant C.J., *McCool M.A., Abriola L., Surovtseva Y.V., Baserga S.J. A high-throughput assay for directly monitoring nucleolar rRNA biogenesis. Open Biology 2022, doi:10.1098/rsob.210305 *Equal contributions

2021

  • Ogawa L.M., Buhagiar A.F., Abriola L., Leland B.A., Surovtseva Y.V., and Baserga S.J. Increased numbers of nucleoli in a genome-wide RNAi screen reveal proteins that link the cell cyle to RNA polymerase I transcription. Molecular Biology of the Cell 2021, doi:10.1091/mbc.E20-10-0670.

  • Harold C.M., Buhagiar A.F., Cheng Y., and Baserga S.J. Ribosomal RNA Transcription Regulation in Breast Cancer. Genes 2021, doi:10.3390/genes12040502.

  • Bryant C.J., Lorea C.F., Larangeira de Almedia H., Weinert L., Vedolin L., Pinto E Vairo F., Baserga S.J. Biallelic splicing variants in the nucleolar 60S assembly factor RBM28 cause the ribosomopathy ANE syndrome. PNAS 2021. doi:10.1073/pnas.2017777118.

  • Claydon J., Farley-Barnes K.I., Baserga S.J. Building skill-sets, confidence, and interest for diverse scientific careers in the biological and biomedical sciences. FASEB Bioadvances 2021. doi:10.1096/fba.2021-00087

2020

  • *McCool M.A., *Bryant C.J., and Baserga S.J. MicroRNAs and long non-coding RNAs as novel regulators of ribosome biogenesis. Biochemical Society Transactions 2020, doi.org/10.1042/BST20190854. *Equal contributions

2019

  • Farley-Barnes K.I.,* Ogawa L.M.*, and Baserga S.J. Ribosomopathies: Old Concepts, New Controversies. Trends in Genetics 2019, doi: 10.1016/j.tig.2019.07.004. *Equal contributions
  • Sondalle S.B., Longerich S, Ogawa L.M., Sung P., and Baserga S.J. Fanconi anemia protein FANCI functions in ribosome biogenesis. PNAS 2019, 116 (7) 2561-2570.

2018

  • Farley-Barnes, K.I., McCann, K.L., Ogawa, L.M., Merkel, J., Surovtseva, Y.V., and Baserga, S.J. Diverse regulators of human ribosome biogenesis discovered by changes in nucleolar number. Cell Reports 22, 1923-1934. http://www.cell.com/cell-reports/pdf/S2211-1247(18)30105-0.pdf

2017

  • Sondalle, S.B. and Baserga, S.J. Ribosomes Need Straight A’s to Sleep. Cell 169:565-567. doi:10.1016/j.cell.2017.04.019 (2017).
  • Tao, T., Sondalle, S.B., Shi, H., Perez-Atayde, A.R., Peng, J., Baserga, S.J., and Look, A.T. The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma. Oncogene. doi:10.1038/onc.2016.527 (2017).
  • Paolini, N. A.*, Attwood, M.*, Sondalle, S.B.*, Marques dos Santos Vieira, C.*, van Adriche, A.M., di Summ, F., O’Donohue, M.F., Gleizes, P.E., Rachuri, S., Briggs, J.W., Fischer, R., Ratcliffe, P.J., Wlodarski, M.W., Houtkooper, R.H., von Lindern, M., Kuijpers, T.W.. Dinman, J.D., Baserga, S.J., Cockman, M.E., MacInnes, A.W.  A novel ribosomopathy reveals decoding defective ribosomes driving human dysmorphism.  American Journal of Human Genetics 100:506-522 (2017). *these authors contributed equally.  PMC5339345.
  • Ogawa, L.M. and Baserga, S.J. Crosstalk between the nucleolus and the DNA damage response. Molecular BioSystems 13:443-455 (2017). PMC5340083.

2016

  • Robson, A., Owens, N.D.L., Baserga, S.J., Khokha, M.K., and Griffin, J.N.  Expression of ribosomopathy genes during Xenopus tropicalis embryogenesis. BMC Developmental Biology (2016) 16:38, 1-13. PMC5081970.
  • Yip, W.S.V., Shigematsu, H., Taylor, D.W. and Baserga, S.J.  Box C/D sRNA stem ends act as stabilizing anchors for box C/D di-sRNPs.  Nucleic Acids Research 44:8976 (2016). PMC5062973.
  • McCann, K.L., Teramoto, T., Zhang, J., Hall, T.M.T.* and Baserga, S.J.*  The molecular basis for ANE syndrome revealed by the large ribosomal subunit processome interactome.  eLIFE  5:e16381 (2016). PMC4859800.  *co-corresponding authors

2015

  • McCann, K.L., Charette, J.M., Vincent, N.G., and Baserga, S.J.  A protein interaction map of the LSU processome. Genes & Development 29: 862-875 (2015).  PMC4403261.
  • Griffin, J.N., Sondalle, S.B., del Viso, F., Baserga, S.J.* & Khokha, M.K.* The ribosome biogenesis factor Nol11 is required for optimal rDNA transcription and craniofacial development in Xenopus. PLoS Genetics 11(3): e1005018. doi:10.1371/journal.pgen.1005018 (2015).  PMC4354908.   *co-corresponding authors

2014

  • Qiu, C., McCann, K.L., Wine, R.N., Baserga, S.J.*, and Hall, T.M.T*. A divergent Pumilio repeat protein family for pre-rRNA processing and mRNA localization. Proc. Natl. Acad. Sci. USA 111: 18554-18559 (2014).  PMC4284587  *co-corresponding authors
  • Zhao, C., Andreeva, V., Gibert, Y., Laonty, M., Lattanzi, V., Prabhudeai, S., Zhou, Y., Zon, L., McCann, K.L., Baserga, S.J. and Yelick, P. Tissue specific roles for the ribosome biogenesis factor Wdr43 in zebrafish development. PLoS Genetics 10(1):e1004074 (2014). PMC3907300.

2013

  • McCann, K.L. and Baserga, S.J. Mysterious ribosomopathies.  Science 341: 849-50 (2013). PMC3893057.

2012

  • Richardson L.A., Reed B.J., Charette J.M., Freed E.F., Fredrickson E.K., Locke M.N., Baserga S.J., Gardner R.G. A conserved deubiquitinating enzyme controls cell growth by regulating RNA polymerase I stability. Cell Reports 2: 372-385 (2012). PMC3638920.
  • Freed, E.F., Prieto, J.L., McCann, K.L., McStay, B. and Baserga, S.J. NOL11, implicated in the pathogenesis of North American Indian Childhood Cirrhosis, is required for pre-rRNA transcription and processing. PLoS Genetics  8:e1002892 (2012). PMC3420923.
  • Bower-Phipps, K.R., Taylor, D.W., Wang, H.W. and Baserga, S.J. The box C/D sRNP dimeric architecture is conserved across domain Archaea. RNA 18:1527-40 (2012). PMC3404373.

2011

  • Dutca, L., Gallagher, J.E., and Baserga, S.J. The initial U3 snoRNA:pre-rRNA base-pairing interaction required for pre-18S rRNA folding revealed by in vivo chemical probing.  Nuc. Acids Res. 39: 5164-80 (2011). PMC3130255.

2010

  • Bleichert, F. and Baserga, S.J.  Dissecting the role of conserved box C/D sRNA sequences in di-sRNP assembly and function.  Nuc. Acids Res. 38:8295-305 (2010). PMC3001065.

2009

  • Bleichert. F., Gagnon, K.T. Brown II, B.A Maxwell, E.S., Leschziner, A.E., Unger, V.M. and Baserga, S.J. A dimeric structure for archaeal box C/D small ribonucleoproteins.  Science 325:1384-1387 (2009). PMC2975540.

2008

  • Champion, E.A., Lane, B.H., Jackrel, M.E., Regan, L. and Baserga, S.J. A direct interaction between the Utp6 half-a tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing. Mol. Cell. Biol. 28: 6547-6556 (2008).

2004

  • Osheim, Y.N., French, S.L., Keck, K.M., Champion, E.A., Spasov, K., Dragon, F., Baserga, S.J. and Beyer, A.L. Pre-18S ribosomal RNA is structurally compacted into the SSU processome prior to being cleaved from nascent transcripts in Saccharomyces cerevisiae. Mol. Cell 16:943-954 (2004).
  • Gallagher, J.E., Dunbar, D.A., Granneman, S., Mitchell, B.M., Osheim, Y., Beyer, A.L. and Baserga, S.J. RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components.  Genes Dev. 18: 2506-2517 (2004).

2002

  • Dragon, F., Gallagher, J.E.G., Compagnone-Post, P.A., Mitchell, B.M., Porwancher, K.A., Wehner, K.A., Wormsley, S., Settlage, R.E., Shabanowitz, J., Osheim, Y., Beyer, A.L., Hunt, D.F. and Baserga, S.J. A large nucleolar U3 ribonucleoprotein required for 18S rRNA biogenesis.  Nature 417: 967-970 (2002).