Crosstalk between the nucleolus and the DNA damage response

Fig. 5 Crosstalk between the nucleolus and the DNA damage response. Diagram of the role of DNA repair proteins in ribosome biogenesis, and conversely the role of ribosome biogenesis proteins in the DNA damage response. (A) Roles for DNA repair proteins in ribosome biogenesis. A number of DNA repair proteins have been localized to the nucleolus. Based on studies of APEX1, WRN, and BLM, these proteins may play important roles in pre-rRNA transcription and pre-rRNA quality control. (B) Roles for ribosome biogenesis factors in the DNA damage response. Evidence also supports a role for proteins involved in ribosome biogenesis to have a dual role in DNA repair. Based on studies of TCOF1, NPM1, NCL, and uS3, these proteins may play important roles in both the recognition of DNA damage and chromatin remodeling at sites of DNA damage, as well as both the functional and transcriptional regulation of DNA repair proteins.
January 23, 2017

Lisa and Susan published their review in Molecular Biosystems on the functional roles of proteins in both ribosome biogenesis and DNA repair! Check it out here:

https://dx.doi.org/10.1039/C6MB00740F

Crosstalk between the nucleolus and the DNA damage response

Nucleolar function and the cellular response to DNA damage have long been studied as distinct disciplines. New research and a new appreciation for proteins holding multiple functional roles, however, is beginning to change the way we think about the crosstalk among distinct cellular processes. Here, we focus on the crosstalk between the DNA damage response and the nucleolus, including a comprehensive review of the literature that reveals a role for conventional DNA repair proteins in ribosome biogenesis, and conversely, ribosome biogenesis proteins in DNA repair. Furthermore, with recent advances in nucleolar proteomics and a growing list of proteins that localize to the nucleolus, it is likely that we will continue to identify new DNA repair proteins with a nucleolar-specific role. Given the importance of ribosome biogenesis and DNA repair in essential cellular processes and the role that they play in diverse pathologies, continued elucidation of the overlap between these two disciplines will be essential to the advancement of both fields and to the development of novel therapeutics.