People

Faculty
Department Bio
Susan J. Baserga's picture Susan J. Baserga
William H. Fleming MD ’57 Professor of Molecular Biophysics and Biochemistry, Professor of Genetics, and Professor of Therapeutic Radiology
Molecular Biophysics and Biochemistry; Genetics; Therapeutic Radiology
research interests

Ribosome Biogenesis; The Nucleolus; Ribosomopathies; Cancer; Human Disease; Eukaryotic Organisms; RNA Biology; Biochemistry and Structural Biology

Biography

Dr. Baserga has a long-standing interest in fundamental aspects of ribosome biogenesis, the nucleolus, human diseases of making ribosomes (ribosomopathies), and on the impact of ribosome biogenesis on cell growth, cell division and cancer. Her laboratory uses a wide-array of biochemical, genetic, and biophysical techniques to study the process and regulation of ribosome biogenesis, and utilizes model systems including yeast, mammalian cells, zebrafish and frogs (Xenopus tropicalis). 
 
See all of Dr. Baserga’s publications here
Mentorship

Dr. Baserga is committed to the education of the next generation of scientists and takes much pride in preparing them for positions in science-related fields. She has had 9 undergraduate, 15 pre-doctoral and 8 post-doctoral trainees who have been very successful as gauged by their publication records, by their success at garnering post-doctoral and faculty positions, and by their ability to obtain their initial grant funding.  In addition to mentoring and advocating for her laboratory trainees, Dr. Baserga was Associate Director of the Yale MD/PhD program for 11 years, and is now the Program Director for the largest graduate student training grant at Yale University.  In 2014, she won the Charles W. Bohmfalk Prize for teaching the basic science of biochemistry to medical students at the Yale School of Medicine.  And, in 2016, she won the William C. Rose award from the American Society of Biochemistry and Molecular Biology (ASBMB) for scientific excellence and mentoring.  She has served for 5 years on BRT-A, one of the NIH study sections that reviews pre-doctoral training grants, and has reviewed training grants for 2 more years on Special Emphasis Panels, one of which she chaired.  In 2015, she reviewed NRSA fellowship applications for the NIH, and in 2016 reviewed nationwide Institutional Beckman Scholar Program applications that benefit undergraduates who want to pursue science as a career. 
Education and training

Institution and location Degree Year field of study
Yale College, New Haven, CT B.S., summa cum laude 1980 Biology
Yale School of Medicine, New Haven, CT M.D., cum laude 1988 Medicine
Yale University, New Haven, CT PH.D. 1988 Human Genetics
Yale University, New Haven, CT Post-doctoral fellowship 1988-1993 Molecular Biophysics and Biochemistry
Curriculum vitae

Check out Dr. Baserga’s full curriculum vitae here.

Graduate Students
Department Bio
Tyler Brown's picture Tyler Brown
Ph.D. student
Genetics
Carson Bryant's picture Carson Bryant
Ph.D. Candidate
Molecular Biophysics and Biochemistry

Carson is investigating genetic variants in human ribosome biogenesis factors that cause developmental defects in the head and brain. He is also studying essential signaling factors in early embryogenesis that are important regulators of ribosome biogenesis.

Link to publications:

https://orcid.org/0000-0002-7475-875X

Select honors and awards:

  • RNA Society Travel Fellowship (2020)
  • Cellular and Molecular Biology Predoctoral Training Grant, NIGMS T32GM007223, National Institutes of Health (2018-2020)
Yan Cheng's picture Yan Cheng
Ph.D. student
Genetics
Cecelia Harold's picture Cecelia Harold
Ph.D. Candidate
Genetics

 Select honors and awards:

  • National Science Foundation (NSF) Graduate Research Fellowship (2020-present)
  • NASA CTSGC Graduate Research Fellowship Grant, NASA Connecticut Space Grant Consortium (2019)
Mason McCool's picture Mason McCool
Ph.D. Candidate
Molecular Biophysics and Biochemistry

Mason is following up on newly discovered regulators of ribosome biogenesis that are additionally implicated in known oncogenic pathways. His work will focus on the molecular mechanisms that connect these pathways to the increased ribosome production often observed in cancer cells.

Link to publications:

https://orcid.org/0000-0001-7834-0927

Select honors and awards:

  • Ruth L. Kirschstein National Research Service Award, F31DE030332, National Institutes of Health (2020-present)
  • Cellular and Molecular Biology Predoctoral Training Grant, NIGMS T32GM007223, National Institutes of Health (2018-2020)
Lisa Ogawa McLean's picture Lisa Ogawa McLean
Ph.D. Candidate
Molecular Biophysics and Biochemistry

The goal of Lisa’s research is to identify previously unknown regulators of mammalian ribosome biogenesis. The foundation of her research is a genome-wide screen that identified ~200 putative ribosome biogenesis factors. Hits range from expected factors such as ribosomal proteins, to proteins involved in embryonic development and neurodegenerative disease.

Link to publications:

http://orcid.org/0000-0001-6841-059X

Select honors and awards:

  • Yale Center for RNA Science and Medicine Service Award (2020)
  • Canaan-Yale Fellowship, Office of Cooperative Research (2019-2020)
  • Yale Center for RNA Science and Medicine Service Award (2019)
  • Ruth L. Kirschstein National Research Service Award, ​F31AG058405, National Institutes of Health (2017-present)
  • Cellular and Molecular Biology Predoctoral Training Grant, NIGMS T32GM007223, National Institutes of Health (2015-2017)
  • Yale-Bristol-Myers Squibb Educational Alliance Internship (2015)
Postbaccalaureates
Department Bio
Amber Buhagiar's picture Amber Buhagiar
Postgraduate Associate
Molecular Biophysics and Biochemistry

Amber is fascinated by the nucleolus and other phase-separated cellular bodies and the biophysical properties that maintain them.

Staff
Department Bio
Katherine Farley-Barnes's picture Katherine Farley-Barnes, Ph.D.
Associate Research Scientist
Molecular Biophysics and Biochemistry
Katie is the Special Assistant for Training Program Development for the Cellular, Molecular, and Quantitative Biology Training Grant
 
Link to publications:
Laura Raymond's picture Laura Raymond
Administrative Assistant
Phone: +1 (203) 785-2984
Molecular Biophysics and Biochemistry

Provides part-time administrative support to the Baserga lab. She has a BA and MA in Fine Art from Connecticut College and Southern CT State University, respectively, and a MALS in English (Oral Storytelling) from Wesleyan University.  During the past 50 years she has been a graduate art student, artist, art dealer, fine art program director and a research science administrator.  Now, semi-retired, she devotes more time and energy to her painting. 

Colors and shapes are my passion.  I think of color as one of the divine aspects of creation.  As with music and math, color is a universal language. The possibilities for color and shape combinations are infinite.” -Laura Raymond

Undergraduate Students
Department Bio
Maya Overton's picture Maya Overton
Undergraduate
Molecular, Cellular, and Developmental Biology; Economics

Maya’s work in the lab is focused on advancing our understanding of the nucleolar stress response in higher eukaryotes.